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Author Chawes, B.L.K.; Buchvald, F.; Bischoff, A.L.; Loland, L.; Hermansen, M.; Halkjaer, L.B.; Bonnelykke, K.; Bisgaard, H. url  doi
  Title Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze Type Journal Article
  Year (down) 2010 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 182 Issue 2 Pages 138-142  
  Keywords Asthma/epidemiology; Breath Tests; Cell Count; Child; Eosinophils/metabolism; *Exhalation; Female; Follow-Up Studies; Humans; Immunoglobulin E/blood; Infant, Newborn; Male; Mothers; Nitric Oxide/*metabolism; Prospective Studies; Recurrence; Respiratory Function Tests; *Respiratory Sounds; Tobacco Smoke Pollution  
  Abstract RATIONALE: Elevated fractional exhaled nitric oxide (Fe(NO)) concentration has been suggested to predict early childhood wheeze and sensitization. OBJECTIVES: To investigate the association between Fe(NO) in asymptomatic neonates and the development of wheeze patterns and atopic intermediary phenotypes in the first 6 years of life. METHODS: We measured Fe(NO) in 253 healthy 1-month-old neonates from the Copenhagen Prospective Study on Asthma in Childhood birth cohort and monitored prospectively wheezy episodes by daily diary cards during the first 6 years of life. Total IgE, specific IgE, and blood eosinophil count were assessed at age 6 months, 4 years, and 6 years. Associations were studied by Cox regression, logistic regression, and generalized linear models. MEASUREMENTS AND MAIN RESULTS: Increased neonatal Fe(NO) level was significantly associated with the development of recurrent wheeze in the first year of life (hazard ratio, 2.63; 95% confidence interval, 1.1 to 6.2; P = 0.026) but not thereafter. The association was unaffected by environmental tobacco smoke exposure. Fe(NO) was not associated with elevated levels of total IgE, specific IgE, or blood eosinophil count at any age point and was unrelated to neonatal lung function. CONCLUSIONS: An elevated Fe(NO) level in asymptomatic neonates born to mothers with asthma preceded the development of transient early wheezing, but not persistent wheezing during preschool age, and was unrelated to atopy. This suggests an early disease process other than small airway caliber contributing to the transient wheezing phenotype.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, 2820 Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Chawes, B.L.K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20299533 Approved no  
  Call Number Serial 150  
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