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Author Chawes, B.L.K.; Kreiner-Moller, E.; Bisgaard, H. url  doi
  Title Upper and lower airway patency are associated in young children Type Journal Article
  Year (down) 2010 Publication Chest Abbreviated Journal Chest  
  Volume 137 Issue 6 Pages 1332-1337  
  Keywords Adrenergic alpha-Agonists/administration & dosage; Adrenergic beta-Agonists/administration & dosage; Airway Obstruction/*physiopathology; Anthropometry; Asthma/*physiopathology; Biomarkers/analysis; Child; Eosinophilia/diagnosis; Female; Forced Expiratory Volume; Humans; Immunoglobulin E/analysis; Linear Models; Male; Nitric Oxide/analysis; Prospective Studies; Rhinitis, Allergic, Seasonal/*physiopathology; Rhinometry, Acoustic; Spirometry  
  Abstract BACKGROUND: Although allergic rhinitis and asthma frequently coexist, the nature of this association is poorly understood. Therefore, we examined whether upper and lower airway patency are associated. METHODS: We investigated 221 6-year-old children from the Copenhagen Prospective Study on Asthma in Childhood birth cohort, assessing upper airway patency by acoustic rhinometry before and after alpha-agonist, and lower airway patency by spirometry before and after beta2-agonist. Furthermore, we measured blood eosinophil count, nasal eosinophilia, total IgE, and fraction of exhaled nitric oxide. Associations were investigated by generalized linear models. RESULTS: Decongested nasal airway patency and post-beta2 FEV(1) were significantly associated (P = .007). The association remained significant after adjustments for sex, body size, FVC, and atopic diseases (beta-coefficient 2.85 cm(3); 95% CI, 0.42 to 5.29; P = .02). Baseline values of upper and lower airway patency were also significantly associated (beta-coefficient 0.89 cm(3); 95% CI, 0.26-1.51; P = .01). In addition, blood eosinophil count and nasal eosinophilia were inversely associated with decongested nasal airway patency, beta-coefficient -0.42 cm(3) (95% CI, -0.77 to -0.07; P = .02) and beta-coefficient -0.47 cm(3) (95% CI, -0.89 to -0.05; P = .03), respectively. CONCLUSIONS: We found a strong and consistent association between upper and lower airway patency. This may be due to a common pathology, as suggested by the inverse association between decongested nasal airway patency, blood eosinophil count, and nasal eosinophilia. Alternatively, the association between upper and lower airway patency might reflect a physiologic background for the common comorbidity.  
  Address Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,483 First Author Chawes, B.L.K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0012-3692 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20118204 Approved no  
  Call Number Serial 149  
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