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Author Brasholt, M.; Baty, F.; Bisgaard, H. url  doi
  Title Physical activity in young children is reduced with increasing bronchial responsiveness Type Journal Article
  Year (down) 2010 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 125 Issue 5 Pages 1007-1012  
  Keywords Airway Resistance; Asthma/*physiopathology; Bronchial Hyperreactivity/*physiopathology; Child, Preschool; Cohort Studies; Exercise/physiology; Female; Humans; Male; *Motor Activity; Nitric Oxide/analysis; Principal Component Analysis; Respiratory Function Tests  
  Abstract BACKGROUND: Physical activity is essential for young children to develop adequately and for quality of life. It can be lower in children with subclinical asthma, and therefore methods to reveal subclinical reduction in physical activity in young children are warranted. OBJECTIVE: We sought to study an association between physical activity in preschool children and objectively assessed intermediary asthma phenotypes. METHODS: We studied 253 five-year-old children (127 girls) participating in the Copenhagen Prospective Studies on Asthma in Childhood. The main outcome measure was level of physical activity assessed objectively with accelerometers worn on an ankle for 4 weeks. Objective assessment of asthma intermediary phenotypes included prebronchodilator and postbronchodilator specific airway resistance, bronchial responsiveness to cold dry-air hyperventilation, and exhaled nitric oxide levels. Analyses were performed with generalized linear model and principal component analysis. RESULTS: Physical activity was inversely associated with bronchial responsiveness (relative rate, 0.89; 95% CI, 0.83-0.95; P = .007) and significantly increased in the months of spring and summer (P < .001) and in boys (relative rate, 1.16; 95% CI, 1.09-1.25; P < .001). Physical activity was independent of asthma diagnosis, age, body mass index, baseline specific airway resistance, reversibility to beta(2)-agonist, sensitization, and exhaled nitric oxide level. CONCLUSION: Physical activity in preschool children was reduced with increasing bronchial responsiveness. The reduced physical activity was subclinical and not realized by parents or doctors despite daily diary cards and close clinical follow-up since birth. This observation warrants awareness of even very mild asthma symptoms in clinical practice.  
  Address Copenhagen Prospective Studies on Asthma in Childhood; the Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen; and Copenhagen University Hospital, Gentofte, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Brasholt, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20392480 Approved no  
  Call Number Serial 147  
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