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Author Giwercman, C.; Halkjaer, L.B.; Jensen, S.M.; Bonnelykke, K.; Lauritzen, L.; Bisgaard, H. url  doi
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  Title Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants Type Journal Article
  Year (down) 2010 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 125 Issue 4 Pages 866-871  
  Keywords Breast Feeding/*adverse effects; Cohort Studies; Denmark/epidemiology; Eczema/diagnosis/*epidemiology/*etiology; Fatty Acids/analysis; Female; Humans; Infant; Male; Milk, Human/chemistry; Respiratory Sounds/diagnosis/*etiology/physiopathology; Risk Assessment; Risk Factors  
  Abstract BACKGROUND: Breast-feeding is recommended for the prevention of eczema, asthma, and allergy, particularly in high-risk families, but recent studies have raised concern that this may not protect children and may even increase the risk. However, disease risk, disease manifestation, lifestyle, and the choice to breast-feed are interrelated, and therefore, analyzing true causal effects presents a number of methodologic challenges. OBJECTIVE: First, to assess the effect from duration of exclusive breast-feeding on the development of eczema and wheezy disorders during the first 2 years of life in a high-risk clinical birth cohort. Second, to assess any influence from the fatty acid composition of mother's milk on the risk from breast-feeding. METHODS: We studied disease development during the first two years of life of the 411 infants from the Copenhagen Study on Asthma in Childhood (COPSAC) birth cohort, born to mothers with a history of asthma. We analyzed the effect from duration of breast-feeding before disease onset on the disease risk, avoiding the effect from disease-related modification of exposure (inverse causation). Polyunsaturated fatty acids were measured in breast milk. RESULTS: Breast-feeding significantly increased the risk of eczema adjusted for demographics, filaggrin variants, parents' eczema, and pets at home (N = 306; relative risk, 2.09; 95% CI 1.15-3.80; P = .016) but reduced the risk of wheezy episodes (relative risk, 0.67; 95% CI 0.48-0.96; P = .021) and of severe wheezy exacerbation (relative risk, 0.16; 95% CI 0.03-1.01; P = .051). There was no association between the fatty acid composition of mother's milk and the risk of eczema or wheeze. CONCLUSION: The risk of eczema was increased in infants with increasing duration of breast-feeding. In contrast, the risk of wheezy disorder and severe wheezy exacerbations was reduced. There were no significant effects from the fatty acid composition of the breast milk on risk of eczema or wheezy disorders.  
  Address Copenhagen Prospective Study on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Giwercman, C. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20236698 Approved no  
  Call Number Serial 146  
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