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Author Raaschou-Nielsen, O.; Hermansen, M.N.; Loland, L.; Buchvald, F.; Pipper, C.B.; Sorensen, M.; Loft, S.; Bisgaard, H. url  doi
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  Title Long-term exposure to indoor air pollution and wheezing symptoms in infants Type Journal Article
  Year (down) 2010 Publication Indoor air Abbreviated Journal Indoor Air  
  Volume 20 Issue 2 Pages 159-167  
  Keywords Air Pollution, Indoor/*adverse effects; Denmark; Humans; Infant; Infant, Newborn; Inhalation Exposure/*adverse effects; Nitrogen Oxides/adverse effects/analysis; Prospective Studies; Respiratory Sounds/etiology/*physiopathology; Time Factors  
  Abstract Long-term exposure to air pollution is suspected to cause recurrent wheeze in infants. The few previous studies have had ambiguous results. The objective of this study was to estimate the impact of measured long-term exposure to indoor air pollution on wheezing symptoms in infants. We monitored wheezing symptoms in diaries for a birth cohort of 411 infants. We measured long-term exposure to nitrogen oxides (NO(x)), NO(2), formaldehyde, PM(2.5) and black smoke in the infants' bedrooms and analyzed risk associations during the first 18 months of life by logistic regression with the dichotomous end-point 'any symptom-day' (yes/no) and by standard linear regression with the end-point 'number of symptom-days'. The results showed no systematic association between risk for wheezing symptoms and the levels of these air pollutants with various indoor and outdoor sources. In conclusion, we found no evidence of an association between long-term exposure to indoor air pollution and wheezing symptoms in infants, suggesting that indoor air pollution is not causally related to the underlying disease. Practical Implications Nitrogen oxides, formaldehyde and fine particles were measured in the air in infants' bedrooms. The results showed no evidence of an association between long-term exposure and wheezing symptoms in the COPSAC birth cohort.  
  Address Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen O, Denmark  
  Corporate Author Thesis  
  Impact Factor 04,904 First Author Raaschou-Nielsen, O. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0905-6947 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20028431 Approved no  
  Call Number Serial 145  
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