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Author Kindlund, K.; Thomsen, S.F.; Stensballe, L.G.; Skytthe, A.; Kyvik, K.O.; Backer, V.; Bisgaard, H. url  doi
  Title Birth weight and risk of asthma in 3-9-year-old twins: exploring the fetal origins hypothesis Type
  Year (down) 2010 Publication Thorax Abbreviated Journal Thorax  
  Volume 65 Issue 2 Pages 146-149  
  Keywords Anthropometry/methods; Apgar Score; Asthma/*embryology/epidemiology; *Birth Weight; Child; Child, Preschool; Denmark/epidemiology; Diseases in Twins/*embryology/epidemiology; Epidemiologic Methods; Female; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects; Twins, Dizygotic; Twins, Monozygotic  
  Abstract AIM: To examine the relationship between birth weight and risk of asthma in a population of twins. METHODS: Birth weight of all live twins (8280 pairs) born in Denmark between 1994 and 2000 was linked to information on asthma obtained from parent-completed questionnaires at age 3-9 years. Conditional logistic regression was used to calculate the risk of asthma. RESULTS: Subjects with a history of asthma at age 3-9 years weighed on average 122 g (95% CI 85 to 160) less at birth than subjects who had not developed asthma, p<0.001. There was a linear increase in asthma risk with decreasing birth weight, OR (per 100 g) 1.04 (95% CI 1.03 to 1.05), p<0.001. Within twin pairs, the lower birthweight twin had a significantly increased risk of asthma compared with the heavier co-twin (11.3% vs 9.9%), OR 1.30 (95% CI 1.10 to 1.54), p=0.002. The result remained significant after adjusting for sex, birth length and Apgar score, OR 1.31 (95% CI 1.03 to 1.65), p=0.027. The risk tended to be higher in monozygotic co-twins compared with dizygotic co-twins, especially for high birth weight differences. CONCLUSIONS: Low birth weight is a risk factor for asthma independently of gestational age, sex, birth length and Apgar score, but this may be due, in part, to residual non-genetic confounding factors. This finding lends support to the “fetal origins hypothesis” suggesting undisclosed prenatal determinants for the risk of asthma.  
  Address Department of Respiratory Medicine, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark  
  Corporate Author Thesis  
  Impact Factor 08,290 First Author Kindlund, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0040-6376 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19996338 Approved no  
  Call Number Serial 144  
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