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Author Thomsen, S.F.; van der Sluis, S.; Stensballe, L.G.; Posthuma, D.; Skytthe, A.; Kyvik, K.O.; Duffy, D.L.; Backer, V.; Bisgaard, H. url  doi
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  Title Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study Type
  Year (down) 2009 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 179 Issue 12 Pages 1091-1097  
  Keywords Antigens, Viral/*analysis; Asthma/epidemiology/*etiology; Child; Child, Preschool; Denmark/epidemiology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Hospitalization/statistics & numerical data; Humans; Incidence; Male; Models, Theoretical; Prognosis; *Registries; Respiratory Syncytial Virus Infections/*complications/epidemiology/virology; Respiratory Syncytial Virus, Human/*immunology; Retrospective Studies; Risk Factors; Twins/*genetics  
  Abstract RATIONALE: Severe respiratory syncytial virus (RSV) infection is associated with asthma but the nature of this association is imperfectly understood. OBJECTIVES: To examine the nature of the association between severe RSV infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. MEASUREMENTS AND MAIN RESULTS: RSV hospitalization and asthma were positively associated (r = 0.43), and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model in which asthma “causes” RSV hospitalization fitted the data significantly better (P = 0.39 for deterioration in model fit) than a model in which RSV hospitalization “causes” asthma (P < 0.001 for deterioration in model fit), even when sex, birth weight, and maternal smoking during pregnancy were accounted for. CONCLUSIONS: RSV infection that is severe enough to warrant hospitalization does not cause asthma but is an indicator of the genetic predisposition to asthma.  
  Address Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen NV, Denmark. sft@city.dk  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Thomsen, S.F. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19286626 Approved no  
  Call Number Serial 139  
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