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Author Bisgaard, H.; Halkjaer, L.B.; Hinge, R.; Giwercman, C.; Palmer, C.; Silveira, L.; Strand, M. url  doi
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  Title Risk analysis of early childhood eczema Type Journal Article
  Year (down) 2009 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 123 Issue 6 Pages 1355-60.e5  
  Keywords Alleles; Child, Preschool; Denmark/epidemiology; Eczema/drug therapy/*epidemiology/genetics; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Hydrocortisone/therapeutic use; Infant; Infant, Newborn; Intermediate Filament Proteins/genetics; Logistic Models; Male; Monte Carlo Method; Mutation/genetics; Prevalence; Prospective Studies; Risk Factors  
  Abstract BACKGROUND: The increasing prevalence of eczema suggests the role of environmental factors triggering a genetic predisposition. OBJECTIVE: To analyze the effect of environmental exposures in early life and genetic predisposition on the development of eczema before age 3 years. METHODS: The Copenhagen Study on Asthma in Childhood is a prospective clinical study of a birth cohort of 411 children born of mothers with asthma. Eczema was diagnosed, treated, and monitored at the clinical research unit, and complete follow-up for the first 3 years of life was available for 356 children. Risk assessments included filaggrin loss-of-function mutation; parent's atopic disease; sex; social status; previous deliveries; third trimester complications and exposures; anthropometrics at birth; month of birth; duration solely breast-fed; introduction of egg, cow's milk, and fish; time spent in day care; cat and dog at home; feather pillow; nicotine in infant's hair; and temperature and humidity in bedroom. RESULTS: Eczema developed in 43.5% of the infants. Filaggrin mutation (odds ratio [OR], 3.20; 95% CI, 1.46-7.02; P = .004), mother's eczema (OR, 2.80; 95% CI, 1.70-4.63; P < .0001), and father's allergic rhinitis (OR, 1.91; 95% CI, 1.09-3.33; P = .02) were directly associated with risk of eczema. Risk of eczema was significantly reduced by birth length (OR per cm increase, 0.87; 95% CI, 0.78-0.97; P = .02), increased bedroom temperature (probably inverse causality; OR, 0.80; 95% CI, 0.66-0.97; P = .02), and dog living in the home (OR, 0.44; 95% CI, 0.23-0.87; P = .02). CONCLUSIONS: Dog exposure reduced the risk of eczema, whereas short length at birth, filaggrin mutation, and parental atopy increased the risk of eczema by age 3 years.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark. bisgaard@copsac.com  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Strand, M.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19501236 Approved no  
  Call Number Serial 136  
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