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Author Bisgaard, H.; Loland, L.; Holst, K.K.; Pipper, C.B. url  doi
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  Title Prenatal determinants of neonatal lung function in high-risk newborns Type Journal Article
  Year (down) 2009 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 123 Issue 3 Pages 651-7, 657.e1-4  
  Keywords Body Mass Index; Bronchial Hyperreactivity/*epidemiology/*physiopathology; Denmark/epidemiology; Female; Forced Expiratory Volume; Humans; Infant, Newborn; Lung/embryology/*physiopathology; Male; *Maternal-Fetal Exchange; Methacholine Chloride; Pregnancy; Prenatal Nutritional Physiological Phenomena; Prospective Studies; Respiratory Sounds/physiology; Risk Factors; Smoking/adverse effects; Spirometry  
  Abstract BACKGROUND: Neonatal lung function is suspected to be associated with wheezy disorders, but little is known about risk factors for the early lung function. OBJECTIVES: To study prenatal determinants of neonatal lung function. METHODS: This is a clinical, prospective birth cohort study of 411 newborns, the Copenhagen Prospective Study on Asthma in Childhood, in a single-center research clinic dedicated solely to this longitudinal birth cohort study. Lung function was determined at 1 month of age by infant spirometry (the raised volume rapid thoraco-abdominal compression technique) and bronchial responsiveness to methacholine by transcutaneous oxygen measurements. Risk factor analyses included anthropometrics; demographics; socioeconomic factors; parental atopic history; previous deliveries; exposures during the third trimester to the mother's smoking, alcohol, and medicines; third trimester pregnancy complications including mother's asthma status; and mode of delivery. RESULTS: Lung function was determined in 404 neonates, age 6 weeks. Neonates with body mass index in the upper quartile had 14% lower baseline forced expiratory volume at 0.5 second, and neonates of mothers smoking during the third trimester had 7% lower baseline forced expiratory volume at 0.5 second. Sex or parental atopic disease did not affect the neonatal lung function and bronchial responsiveness. Maternal intake of paracetamol during the third trimester was associated with doubling of the bronchial responsiveness in the neonates, but the statistical significance may have been driven by outliers. Bronchial responsiveness exhibited a parabola development with tripling of bronchial responsiveness reaching the nadir at 3 months of age, but this needs replication in a study with repetitive measurements within individuals. CONCLUSION: High body mass index in newborns and mothers smoking is associated with reduced neonatal lung function. This suggests that the association between body proportion and wheezing disorders may be a result of shared genes or prenatal nutrition.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Hellerup, Denmark. Bisgaard@copsac.com  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Pipper, C.B.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19152964 Approved no  
  Call Number Serial 134  
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