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Author Stensballe, L.G.; Simonsen, J.B.; Thomsen, S.F.; Larsen, A.-M.H.; Lysdal, S.H.; Aaby, P.; Kyvik, K.O.; Skytthe, A.; Backer, V.; Bisgaard, H. url  doi
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  Title The causal direction in the association between respiratory syncytial virus hospitalization and asthma Type
  Year (down) 2009 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 123 Issue 1 Pages 131-137.e1  
  Keywords Asthma/*epidemiology/virology; Child; Child, Preschool; Denmark; Environmental Exposure; Female; Genetic Predisposition to Disease; Hospitalization; Humans; Infant; Infant, Newborn; Male; *Registries; Respiratory Syncytial Virus Infections/*epidemiology; *Respiratory Syncytial Viruses; Risk Factors; Time Factors  
  Abstract BACKGROUND: Earlier studies have reported an increased risk of asthma after respiratory syncytial virus (RSV) hospitalization. Other studies found that asthmatic disposition and propensity to wheeze increase the risk of RSV hospitalization. OBJECTIVE: The current study examined the causal direction of the associations between RSV hospitalization and asthma in a population-based cohort of twins. METHODS: We conducted a prospective cohort study examining the associations between RSV hospitalization and asthma by using registry information on RSV hospitalization and asthma among 18,614 Danish twins born 1994 to 2003. The associations between RSV and asthma were examined in both directions: we examined the risk of asthma after RSV hospitalization, and the risk of RSV hospitalization in children with asthma in the same population-based cohort. RESULTS: Asthma hospitalization after RSV hospitalization was increased as much as 6-fold to 8-fold during the first 2 months after RSV hospitalization but was no longer increased 1 year later. Asthma increased the risk of RSV hospitalization by 3-fold, and the risk was not time-dependent. Analyzing these associations on the basis of asthma defined from use of inhaled corticosteroid did not materially change the risk estimates. CONCLUSION: There is a bidirectional association between severe RSV infection and asthma. Severe RSV infection is associated with a short-term increase in the risk of subsequent asthma, suggesting that RSV induce bronchial hyperresponsiveness; and asthma is associated with a long-term increased susceptibility for severe RSV disease, suggesting a host factor being responsible for the severe response to RSV infection. This suggests that severe RSV infection and asthma may share a common genetic predisposition and/or environmental exposure.  
  Address Bandim Health Project, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. LGN@ssi.dk  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Stensballe, L.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19130934 Approved no  
  Call Number Serial 132  
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