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Author Giwercman, C.; Lerbaek, A.; Bisgaard, H.; Menne, T. url  doi
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  Title Classification of atopic hand eczema and the filaggrin mutations Type Journal Article
  Year (down) 2008 Publication Contact Dermatitis Abbreviated Journal Contact Dermatitis  
  Volume 59 Issue 5 Pages 257-260  
  Keywords Dermatitis, Atopic/*classification/epidemiology/*genetics; Female; Gene Expression Regulation; Genetic Predisposition to Disease/*epidemiology; Hand Dermatoses/classification/epidemiology/genetics; Humans; Incidence; Intermediate Filament Proteins/*genetics; Male; Mutation; Prognosis; Sensitivity and Specificity  
  Abstract Hand eczema is a common disease with various risk factors of which atopic dermatitis is known to be one of the most important. Recently, two mutations in the gene coding for filaggrin, a protein important for the skin barrier, have repeatedly been shown to be associated with atopic dermatitis. Moreover, one study point towards an association between the filaggrin null alleles and the subgroup of patients having both hand eczema and atopic dermatitis. For the remainder of hand eczema patients, still unknown genetic risk factors exist. We propose that in future, classification of atopic hand eczema should distinguish between patients with and without the filaggrin null alleles and to further differentiate between associations with type I allergy, type IV allergy and exposure to irritants, respectively. Furthermore, we suggest future studies of atopic hand eczema to analyse for the filaggrin mutations. We believe this will increase the possibility of subgrouping this otherwise heterogenic disease and thereby enable a better phenotype-genotype characterization of hand eczema. This could improve the preventive initiatives, secure better information of patients about the prognosis for their disease, and possibly enable targeted treatment.  
  Address Department of Dermatology, Copenhagen University Hospital Gentofte, DK-2900 Hellerup, Denmark. c_giwercman@hotmail.com  
  Corporate Author Thesis  
  Impact Factor 03,747 First Author Giwercman, C. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Menne, T.  
  ISSN 0105-1873 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18976374 Approved no  
  Call Number Serial 128  
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