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Author Kjaer, B.B.; Jensen, J.S.; Nielsen, K.G.; Fomsgaard, A.; Bottiger, B.; Dohn, B.; Bisgaard, H. url  doi
  Title Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood Type Journal Article
  Year (down) 2008 Publication Pediatric Pulmonology Abbreviated Journal Pediatr Pulmonol  
  Volume 43 Issue 6 Pages 567-575  
  Keywords Airway Resistance; Bronchial Hyperreactivity/*diagnosis/*microbiology; Bronchial Provocation Tests; Child, Preschool; Cohort Studies; Female; Humans; Infant; Male; Mycoplasma Infections/complications/*diagnosis/*microbiology; Mycoplasma pneumoniae/*isolation & purification; Plethysmography, Whole Body; Polymerase Chain Reaction; Retrospective Studies  
  Abstract Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with M. pneumoniae in early childhood has a long-term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort-study children younger than 5 years-of-age when PCR-tested for M. pneumoniae were enrolled. Sixty-five children with clinical symptoms suggesting infection with M. pneumoniae during an epidemic season completed a clinical follow-up examination including lung function testing (28 PCR-positive and 37 PCR-negative). In addition to the PCR-test for M. pneumoniae all respiratory tract specimens were additionally tested for other atypical bacteria and for viruses by PCR. Lung function was measured as specific airway resistance by whole-body plethysmography and bronchial hyperresponsiveness was assessed by cold, dry air hyperventilation. Neither baseline lung function nor bronchial response to cold dry air hyperventilation differed between M. pneumoniae-positive and -negative children: mean baseline lung function were 1.17 versus 1.21 (kPa sec), P = 0.45; and mean change in specific resistance was 13% versus 9%, P = 0.42. In conclusion, M. pneumoniae infection in early childhood was not associated with long-term effects on lung function and bronchial hyperresponsiveness 2 years after infection.  
  Address Department of Paediatrics, Copenhagen University Hospital, Glostrup, Denmark.  
  Corporate Author Thesis  
  Impact Factor 02,704 First Author Kjaer, B.B. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1099-0496 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18435477 Approved no  
  Call Number Serial 122  
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