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Author Thomsen, S.F.; Stensballe, L.G.; Skytthe, A.; Kyvik, K.O.; Backer, V.; Bisgaard, H. url  doi
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  Title Increased concordance of severe respiratory syncytial virus infection in identical twins Type Journal Article
  Year (down) 2008 Publication Pediatrics Abbreviated Journal Pediatrics  
  Volume 121 Issue 3 Pages 493-496  
  Keywords Age Distribution; Antigens, Viral/analysis; Child, Preschool; Confidence Intervals; Denmark/epidemiology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Genetic Predisposition to Disease/*epidemiology; Humans; Incidence; Infant; Male; Probability; Proportional Hazards Models; Registries; Respiratory Syncytial Virus Infections/diagnosis/*epidemiology/*genetics; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex Distribution; *Twins, Monozygotic  
  Abstract OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.  
  Address Department of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 60 DK-2400 Copenhagen NV, Denmark. sft@city.dk  
  Corporate Author Thesis  
  Impact Factor 05,473 First Author Thomsen, S.F. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0031-4005 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18310197 Approved no  
  Call Number Serial 120  
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