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Author Bonnelykke, K.; Pipper, C.B.; Bisgaard, H. url  doi
  Title Sensitization does not develop in utero Type Journal Article
  Year (down) 2008 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 121 Issue 3 Pages 646-651  
  Keywords Allergens/immunology; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood/*immunology; Food Hypersensitivity/etiology/immunology; Humans; Hypersensitivity, Immediate/blood/*immunology; Immunoglobulin A/blood; Immunoglobulin E/*blood; Infant; Infant, Newborn; Inhalation Exposure/adverse effects; Pregnancy; Prenatal Exposure Delayed Effects/blood/*immunology  
  Abstract BACKGROUND: Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy. OBJECTIVE: To investigate the relevance of allergen-specific IgE in cord blood to sensitization in early infancy and the origin of such IgE. METHODS: Inhalant and food allergen-specific IgE in cord blood was analyzed and compared with specific IgE in infant blood at 6 months of age and in parental blood. Cord blood IgA was measured to detect maternal blood contamination of cord blood. RESULTS: Allergen-specific IgE, primarily against inhalant allergens, was detected in 14% of cord blood samples. However, corresponding specific IgE was not found in infant blood at 6 months of age. Specific IgE in cord blood completely matched specific IgE in maternal blood with respect to allergen specificity, level of specific IgE, and ratio of total IgE/specific IgE. Finally, there was a correlation between specific IgE and IgA in cord blood. CONCLUSION: Allergen-specific IgE in cord blood does not reflect intrauterine sensitization but seems to be the result of transfer of maternal IgE to the fetus.  
  Address Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark.  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Bonnelykke, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18328892 Approved no  
  Call Number Serial 119  
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