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Author Lerbaek, A.; Bisgaard, H.; Agner, T.; Ohm Kyvik, K.; Palmer, C.N.A.; Menne, T. url  doi
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  Title Filaggrin null alleles are not associated with hand eczema or contact allergy Type
  Year (down) 2007 Publication The British Journal of Dermatology Abbreviated Journal Br J Dermatol  
  Volume 157 Issue 6 Pages 1199-1204  
  Keywords Adult; *Alleles; Cohort Studies; Dermatitis, Contact/*genetics; Female; Genetic Markers; Hand Dermatoses/*genetics; Humans; Intermediate Filament Proteins/*genetics; Longitudinal Studies; Male; Prospective Studies; Skin Tests; Twins, Monozygotic  
  Abstract BACKGROUND: The filaggrin protein is a key component of stratum corneum and homo- or heterozygotes for the filaggrin variant alleles R501X and 2282del4 have varying degrees of impaired skin barrier. The variant alleles have repeatedly been shown to be associated with atopic dermatitis. Any possible association with hand eczema or contact allergy are unexplored. OBJECTIVES: To explore associations between the variant alleles, hand eczema, contact allergy and atopic dermatitis. METHODS: In total, 183 adult individuals participated in a clinical examination of the hands, patch testing and filaggrin genotyping. Children without any evidence of atopic dermatitis from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC) study were used as controls. The chi(2) test was used for comparison of allele frequencies. RESULTS: The majority (73%) had hand eczema, 25% had contact allergy and 14% had a diagnosis of atopic dermatitis. The association between atopic dermatitis and the filaggrin variant alleles was confirmed (odds ratio 3.5, P = 0.015). Allele frequencies in individuals with hand eczema or contact allergy were not statistically significantly increased. CONCLUSION: There is no association between the variant alleles and hand eczema or contact allergy.  
  Address National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Ledreborg Alle 40, 1, 2820 Gentofte, Denmark. anne.lerbaek@dadlnet.dk  
  Corporate Author Thesis  
  Impact Factor 04,275 First Author Lerbaek, A. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Menne, T.  
  ISSN 0007-0963 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17970802 Approved no  
  Call Number Serial 117  
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