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Author Bonnelykke, K.; Jespersen, J.J.; Bisgaard, H. url  doi
openurl 
  Title Age dependent systemic exposure to inhaled salbutamol Type Journal Article
  Year (down) 2007 Publication British Journal of Clinical Pharmacology Abbreviated Journal Br J Clin Pharmacol  
  Volume 64 Issue 2 Pages 241-244  
  Keywords Administration, Inhalation; Adolescent; Age Factors; Albuterol/*administration & dosage/pharmacokinetics; Asthma/*drug therapy; Bronchodilator Agents/*administration & dosage/pharmacokinetics; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Lung/*metabolism; Male  
  Abstract AIMS: To determine the effect of age on systemic exposure to inhaled salbutamol in children. METHODS: Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed. RESULTS: Prescribing a dose on a microg kg(-1) basis caused reduced systemic exposure in young children (Y) compared with older children (O) (C(max-microg kg(-1)-adjusted) Y : O ratio (95%CI) = 0.55 (0.47, 0.65)) whereas a fixed nominal dose irrespective of age caused increased exposure in young children (C(max) Y : O ratio (95%CI) = 1.7 (1.3, 2.2)). CONCLUSIONS: For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.  
  Address Danish Pediatric Asthma Center; Copenhagen University Hospital, Gentofte, Copenhagen, Denmark. kb@copsac.dk  
  Corporate Author Thesis  
  Impact Factor 03,878 First Author Bonnelykke, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0306-5251 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17335545; PMCID:PMC2000621 Approved no  
  Call Number Serial 114  
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