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Author Sorensen, M.; Bisgaard, H.; Stage, M.; Loft, S. url  doi
  Title Biomarkers of exposure to environmental tobacco smoke in infants Type Journal Article
  Year (down) 2007 Publication Biomarkers Abbreviated Journal Biomarkers  
  Volume 12 Issue 1 Pages 38-46  
  Keywords Biomarkers/*analysis/blood; Cohort Studies; Cotinine/*analysis/blood; *Environmental Exposure; Gas Chromatography-Mass Spectrometry; Hair/chemistry; Humans; Infant; Nicotine/*analysis/blood; Sensitivity and Specificity; Smoke/*adverse effects; *Tobacco  
  Abstract Non-invasive biomonitoring of exposure to environmental tobacco smoke (ETS) by means of hair is attractive in children, although systematic evaluation is required in infants. The objective was to compare nicotine and cotinine concentrations in hair and plasma and parentally reported exposure to ETS in a birth cohort of 411 infants. Plasma was collected from 356 six-month-old infants and hair samples were collected from 368 one-year-old infants. Concentrations of nicotine and cotinine were measured by an optimized gas chromatography-mass spectrometry (GC/MS)-based method requiring 4 mg hair or 200 microl plasma. Information was obtained on the number of days with ETS exposure during the first year of life, the smoking habits of the parents, and the number of cigarettes smoked per day in the home. All three parentally reported indices of ETS exposure were significantly associated with the biomarkers, with clear dose response relationships. There was a significant association between days with ETS exposure and nicotine in hair at relatively low exposure levels (10-99 days per year), whereas the other biomarkers only showed significant increases at higher exposure levels. In conclusion, nicotine in hair appears to be the biomarker most strongly associated with parental reports on exposure to ETS in infants.  
  Address Institute of Public Health, University of Copenhagen, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,260 First Author Sorensen, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Loft, S.  
  ISSN 1354-750X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17438652 Approved no  
  Call Number Serial 109  
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