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Author Mortensen, L.J.; Kreiner-Moller, E.; Hakonarson, H.; Bonnelykke, K.; Bisgaard, H. url  doi
  Title The PCDH1 gene and asthma in early childhood Type Journal Article
  Year (down) 2014 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 43 Issue 3 Pages 792-800  
  Keywords Alleles; Asthma/*genetics; Cadherins/*genetics/*metabolism; Cell Adhesion; Child; Child, Preschool; Dermatitis, Atopic/*genetics; Genotype; Humans; Infant; Kaplan-Meier Estimate; Longitudinal Studies; Phenotype; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors  
  Abstract Previous studies have suggested that variants in the protocadherin-1 (PCDH1) gene, which is important for cell-cell adhesion, are associated with asthma, bronchial, hyperresponsiveness and atopic dermatitis in school children. Our aim was to associate common variants of the PCDH1 gene with longitudinally assessed asthma phenotypes and atopic dermatitis in early childhood. We analysed eight single-nucleotide polymorphisms in PCDH1 from 411 children born to asthmatic mothers from the Copenhagen Prospective Studies on Asthma in Childhood birth cohort. Asthma and atopic dermatitis were diagnosed prospectively to the age of 7 years and asthma was categorised by temporal pattern: transient early respiratory symptoms, persistent symptoms and late-onset symptoms. Bronchial responsiveness was measured at age 6 years. We used additive genetic models. Kaplan-Meier plots revealed early onset in hetero- and homozygotes for the rs10063472-T allele. Significant association was observed between the transient early phenotype and rs10063472-T (transient early versus all: OR 1.91, 95% CI 1.21-3.01, p=0.0058; transient early versus asymptomatic: OR 2.00, 95% CI 1.23-3.25, p=0.0053). No association was observed for other symptom patterns or bronchial responsiveness. Significant association was observed for atopic dermatitis and rs11167761-A (OR 1.85, 95% CI 1.24-2.75, p=0.0026). Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood.  
  Address Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,636 First Author Mortensen, L.J. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23988763 Approved no  
  Call Number Serial 107  
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