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Author Bonnelykke, K.; Sleiman, P.; Nielsen, K.; Kreiner-Moller, E.; Mercader, J.M.; Belgrave, D.; den Dekker, H.T.; Husby, A.; Sevelsted, A.; Faura-Tellez, G.; Mortensen, L.J.; Paternoster, L.; Flaaten, R.; Molgaard, A.; Smart, D.E.; Thomsen, P.F.; Rasmussen, M.A.; Bonas-Guarch, S.; Holst, C.; Nohr, E.A.; Yadav, R.; March, M.E.; Blicher, T.; Lackie, P.M.; Jaddoe, V.W.V.; Simpson, A.; Holloway, J.W.; Duijts, L.; Custovic, A.; Davies, D.E.; Torrents, D.; Gupta, R.; Hollegaard, M.V.; Hougaard, D.M.; Hakonarson, H.; Bisgaard, H. url  doi
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  Title A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations Type Journal Article
  Year (down) 2014 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 46 Issue 1 Pages 51-55  
  Keywords Asthma/etiology/*genetics; Cadherins/chemistry/*genetics/metabolism; Case-Control Studies; Child; Child, Preschool; Chromosomes, Human, Pair 17; DNA Repair Enzymes/genetics; DNA-Binding Proteins/genetics; Denmark; Female; *Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Interleukin-33; Interleukins/genetics; Male; Membrane Proteins/chemistry/*genetics/metabolism; Models, Molecular; Neoplasm Proteins/genetics; Polymorphism, Single Nucleotide; Protein Conformation; Receptors, Cell Surface/genetics  
  Abstract Asthma exacerbations are among the most frequent causes of hospitalization during childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide association study of a specific asthma phenotype characterized by recurrent, severe exacerbations occurring between 2 and 6 years of age in a total of 1,173 cases and 2,522 controls. Cases were identified from national health registries of hospitalization, and DNA was obtained from the Danish Neonatal Screening Biobank. We identified five loci with genome-wide significant association. Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. We also obtained strong evidence for a new susceptibility gene, CDHR3 (encoding cadherin-related family member 3), which is highly expressed in airway epithelium. These results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes.  
  Address 1] Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark. [2]  
  Corporate Author Thesis  
  Impact Factor 29,352 First Author Bonnelykke, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24241537 Approved no  
  Call Number Serial 106  
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