toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Record Links
Author Stokholm, J.; Schjorring, S.; Pedersen, L.; Bischoff, A.L.; Folsgaard, N.; Carson, C.G.; Chawes, B.L.K.; Bonnelykke, K.; Molgaard, A.; Krogfelt, K.A.; Bisgaard, H. url  doi
openurl 
  Title Prevalence and predictors of antibiotic administration during pregnancy and birth Type Journal Article
  Year (down) 2013 Publication PloS one Abbreviated Journal PLoS One  
  Volume 8 Issue 12 Pages e82932  
  Keywords Administration, Oral; Adult; Anti-Bacterial Agents/*administration & dosage; Cohort Studies; Denmark; Drug Therapy/*utilization; Female; Humans; Life Style; Maternal Age; Odds Ratio; *Parturition; Pregnancy; Pregnancy Complications, Infectious/drug therapy/epidemiology; Prevalence; Risk Factors  
  Abstract BACKGROUND: Antibiotic treatment during pregnancy and birth is very common. In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in the COPSAC2010 pregnancy cohort, and analyze dependence on social and lifestyle-related factors. METHODS: 706 pregnant women from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) pregnancy cohort participated in this analysis. Detailed information on oral antibiotic prescriptions during pregnancy filled at the pharmacy was obtained and verified longitudinally. Information on intrapartum antibiotics, social, and lifestyle-factors was obtained by personal interviews. RESULTS: The prevalence of antibiotic use was 37% during pregnancy and 33% intrapartum. Lower maternal age at birth; adjusted odds ratio (aOR) 0.94, 95% CI, [0.90-0.98], p = 0.003 and maternal smoking; aOR 1.97, 95% CI, [1.07-3.63], p = 0.030 were associated with use of antibiotics for urinary tract infection during pregnancy. Maternal educational level (low vs. high), aOR 2.32, 95% CI, [1.24-4.35], p = 0.011, maternal asthma; aOR 1.99, 95% CI, [1.33-2.98], p < 0.001 and previous childbirth; aOR 1.80, 95% CI, [1.21-2.66], p = 0.004 were associated with use of antibiotics for respiratory tract infection during pregnancy. Lower gestational age; aOR 0.72, 95% CI, [0.61-0.85], p < 0.001, maternal smoking; aOR 2.84, 95% CI, [1.33-6.06], p = 0.007, and nulliparity; aOR 1.79, 95% CI, [1.06-3.02], p = 0.030 were associated with administration of intrapartum antibiotics in women giving birth vaginally. CONCLUSION: Antibiotic administration during pregnancy and birth may be influenced by social and lifestyle-factors. Understanding such risk factors may guide preventive strategies in order to avoid unnecessary use of antibiotics.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Naestved Hospital, Naestved, Denmark ; Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 03,234 First Author Stokholm, J. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24340068; PMCID:PMC3858309 Approved no  
  Call Number Serial 105  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: