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Author Kreiner-Moller, E.; Chawes, B.L.K.; Vissing, N.H.; Koppelman, G.H.; Postma, D.S.; Madsen, J.S.; Olsen, D.A.; Baty, F.; Vonk, J.M.; Kerkhof, M.; Sleiman, P.; Hakonarsson, H.; Mortensen, L.J.; Poorisrisak, P.; Bisgaard, H.; Bonnelykke, K. url  doi
  Title VEGFA variants are associated with pre-school lung function, but not neonatal lung function Type Journal Article
  Year (down) 2013 Publication Clinical and Experimental Allergy Abbreviated Journal Clin Exp Allergy  
  Volume 43 Issue 11 Pages 1236-1245  
  Keywords Age Factors; Asthma/*genetics/*physiopathology; Bronchial Hyperreactivity/*genetics/*physiopathology; Child, Preschool; Female; *Genetic Variation; Humans; Infant, Newborn; Linkage Disequilibrium; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Prospective Studies; Respiratory Function Tests; Risk Factors; Vascular Endothelial Growth Factor A/*genetics; asthma; child; infant; respiratory function tests; vascular endothelial growth factor A  
  Abstract BACKGROUND: Vascular endothelial growth factor (VEGF) is implicated in airway remodelling and asthma development. We studied VEGFA gene variants and plasma levels and the development of lung function, bronchial hyperresponsiveness and asthma in childhood. METHODS: We analysed 13 SNPs in the VEGFA gene in 411 children from the COPSAC2000 high-risk birth cohort. Asthma was diagnosed prospectively, and lung function measurements were obtained at birth and 6 years of age. Plasma VEGF levels were measured at 18 months of age. We used a Bonferroni adjusted significance level. Findings were replicated in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort at age 8. RESULTS: At age six, three SNPs from the same linkage block were associated with FEV1 (rs699947, P = 1.31E-05), independent of asthma, and there were suggestive associations between FEV1/FVC ratio and rs833052 and maximal mid-expiratory flow and rs6900017. Replication in the PIAMA cohort showed borderline association between FEV1 and rs699947 and significant meta-analysis result. SNPs upstream and nearby rs699947 were nominally associated with VEGF plasma levels. VEGF levels were not associated with asthmatic symptoms or lung function measures. CONCLUSIONS AND CLINICAL RELEVANCE: VEGF gene variants are associated with lung function at school age, but not at birth, suggesting a role of VEGF in post-natal lung function development.  
  Address COPSAC: Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Denmark; The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 04,769 First Author Kreiner-Moller, E. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bonnelykke, K.  
  ISSN 0954-7894 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24152156 Approved no  
  Call Number Serial 102  
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